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. 2016 May 26;6:26807. doi: 10.1038/srep26807

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(a) ND, (b) HFD, (c) HFD + V, (d) HFD + U, (e) HFD + N, (f) HFD + U + N. ND: normal diet group, HFD: high-fat diet group, HFD + V: high-fat diet + saline group, HFD + U: high-fat diet + U50,488H group, HFD + N: high-fat diet + nor-BNI group, HFD + U + N: high-fat diet + U50,488H + nor-BNI group. Our results showed apparent fatty degeneration in rat liver tissue after high-fat diet feeding. Neither U50,488H nor nor-BNI treatment improved the situation.