Skip to main content
. 2016 May 26;6:26807. doi: 10.1038/srep26807

Figure 4.

Figure 4

Effects of U50,488H on NO production in the absence and presence of nor-BNI and PI3K/Akt/eNOS inhibitor in serum (a) and culture medium for HUVECs (b) n = 10 (serum), n = 5 (cell culture medium). Values are mean ± SEM. ND: normal diet group, HFD: high-fat diet group, HFD + V: high-fat diet + saline group, HFD + U: high-fat diet + U50,488H group, HFD + N: high-fat diet + nor-BNI group, HFD + U + N: high-fat diet + U50,488H + nor-BNI group. Con: normal medium group, Con + U: normal medium + U50,488H group, P: palmitate-added medium group, P + U: palmitate-added medium + U50,488H group, P + U + N: palmitate-added medium + U50,488H + nor-BNI group, P + U + LY: palmitate-added medium + U50,488H + LY294002 group, P + U + MK: palmitate-added medium + U50,488H + MK2206-HCl group, P + U + L: palmitate-added medium + U50,488H + L-NAME group. *P < 0.05 vs. ND, #P < 0.05 vs. HFD + V, &P < 0.05 vs. HFD + U (a). **P < 0.01 vs. Con, ##P < 0.01 vs. P, &&P < 0.01 vs. P + U (b).