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Effects of U50,488H on vascular tissue eNOS (a) and iNOS (b) activity in the absence and presence of nor-BNI (n = 10). Values are mean ± SEM. ND: normal diet group, HFD: high-fat diet group, HFD + V: high-fat diet + saline group, HFD + U: high-fat diet + U50,488H group, HFD + N: high-fat diet + nor-BNI group, HFD + U + N: high-fat diet + U50,488H + nor-BNI group. **P < 0.01 vs. ND, #P < 0.05 vs. HFD, &P < 0.05, &&P < 0.01 vs. HFD + V, $P < 0.05, $$P < 0.01 vs. HFD + U.
