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. 2016 May 26;6:26865. doi: 10.1038/srep26865

Figure 6. Expression of NR2B/2A, PSD-95 and synaptophysin is affected by maternal exposure to ketamine.

Figure 6

PFC tissue from P0 and P30 rats were processed for western blots to detect proteins NR2B (a), NR2A (b), synaptophysin (SY-38, e) and PSD-95 (f). The NR2B protein levels in the ketamine group were significantly lower at P0 and higher at P30 compared to the corresponding control samples (a,c). The NR2A protein was expressed at a low level at P0 in both control and ketamine samples (b,d) but was significantly decreased in the ketamine compared to the control at P30 (b,d). The ketamine group expressed significantly less SY-38 at P0 and P30 relatively to controls (e,g). In contrast, there was no significant difference of PSD-95 levels at P0 and more PSD-95 protein in the ketamine group than in the control at P30 (f,h). ctrl-P0, control group at P0; ctrl-P30, control group at P30; ktm-P0, the ketamine group at P0; ktm-P30, ketamine group at P30. *p < 0.05; **p < 0.01, comparison between the control and ketamine group; #p < 0.05; ##p < 0.01, comparison between P0 and P30; n = 6 in each group.