Table 2.

Examples of target moieties in anti-cancer nanoformulations

Target moiety	Nanoformulation	Active compound	Indication	Therapy	Reference
Epidermal growth factor receptor	Peptide-targeted gold nanoparticles	Pc 4	Brain cancer	Photodynamic therapy	[213]
Epidermal growth factor receptor	PLGA nanoparticles	Tylocrebine	Several types of tumors, including epidermoid cancer	Chemotherapy	[214]
Fibrin-associated plasma proteins	CREKA-conjugated dextran-coated iron oxide nanoparticles	Iron oxide NPs	Non-small lung cancer	Hyperthermia	[67]
Fibrin-associated plasma proteins	CREKA-conjugated liposomes	Doxorubicin	Breast cancer	Chemotherapy	[68]
Folate receptors	PLGA polymeric nanoparticles	Doxorubicin	Breast cancer	Chemotherapy	[47]
Folate receptors	Cobalt ferrite nanoparticles	Hematoporphyrin	Several types of FR-positive tumors	Photodynamic therapy	[65]
Folate receptors	Deoxycholic acid-O-carboxymethylated chitosan nanoparticles	Paclitaxel	Breast cancer	Chemotherapy	[25]
IL-13Rɑ2	Liposomes	Doxorubicin	Glioblastoma multiforme	Chemotherapy	[215]
Integrin receptors	RGD-modified liposomes	Paclitaxel	Hepatocellular carcinoma	Chemotherapy	[216]
LHRH receptor	Gold nanorods	Goserelin	Prostate cancer	Radiotherapy	[217]
Transferrin receptors	PEGylated gold nanoparticles	AuNPs	Mouse neuroblastoma	Chemotherapy	[61]
Transferrin receptors	VitE TPGS-encapsulated micelles	Docetaxel	Breast cancer	Chemotherapy	[34]
Transferrin receptors	PLGA polymeric nanoparticles	Methotrexate	Brain cancer	Chemotherapy	[33]