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. 2016 Apr 27;13(5):446. doi: 10.3390/ijerph13050446

Figure 1.

Figure 1

Pancreas histopathological examination and insulin immunohistochemistry from diabetic rats treated with C. papaya extract. (a) Normal control (NC) β-cells from normal islet with a greater content of insulin; (b) Normal rats that received 62 mg/Kg/day of CPLE (NC + CPLE62), large islets have greater insulin content when compared to NC; (c) Diabetic (D), β-cells from small islets have a significantly reduced insulin-positive area; (d) Diabetic rats that received 31 mg/Kg/day of CPLE (D + CPLE31), small islets have a greater density of insulin granules than β-cells from D; (e) Diabetic rats that received 62 mg/Kg/day of CPLE (D + CPLE62), showed a significant increase in positive insulin immunoreactive with respect to pancreas from D; (f) Diabetic rats that received 125 mg/Kg/day of CPLE (D + CPLE125), diffuse islet which has a low density of insulin granules; (g) Diabetic rats that received 5 IU/kg/day of insulin display islets with bigger insulin content.