Table 1.
Statistical association of each SNP with age, sex,VA, and laterality.
| Gene | SNP | Age (≤75 years vs > 75 years) (p value) | Sex (p value) | Better VA (better than 20/200) (p value) | Laterality (bilateral or unilateral) (p value) |
|---|---|---|---|---|---|
| CFH | rs203674 | 0.994 | 0.265 | 0.513 | 0.330 |
| CFH | rs572515 | 0.820 | 0.561 | 0.773 | 0.456 |
| CFH | rs800292 | 0.590 | 0.886 | 0.034 | 0.764 |
| CFH | rs1061147 | 0.800 | 0.977 | 0.444 | 0.822 |
| CFH | rs1061170 | 0.378 | 0.820 | 0.435 | 0.424 |
| CFH | rs2274700 | 0.555 | 0.197 | 0.772 | 0.672 |
| CFH | rs7529589 | 0.424 | 0.539 | 0.591 | 0.515 |
| CFH | rs12038333 | 0.185 | 0.208 | 0.247 | 0.522 |
| CFH | rs35507625 | 0.985 | 0.892 | 0.326 | 0.342 |
| LOC387715/ARMS2 | rs11200638 | 0.672 | 0.472 | 0.262 | 0.635 |
| LOC387715/ARMS2 | rs10664316 | 0.966 | 0.773 | 0.342 | 0.514 |
| HTRA1 | rs2672598 | 0.633 | 0.680 | 0.355 | 0.625 |
SNP: single nucleotide polymorphisms, VA: visual acuity, CFH: complement factor H, ARMS2: age related maculopathy susceptibility 2 gene, HTRA1: HtrA serine peptidase 1 gene.