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Metastatic melanoma infiltrates in the sinusoids of the liver. Residual hepatocytes with pink cytoplasm appear atrophic in-between the abundant melanoma cells (HE, ×200). Inset The neoplastic cells are plasmacytoid with light grey-purple cytoplasm and prominent nucleoli. Scattered melanoma cells exhibit cytoplasmic granular melanin pigment (HE, ×400). Arrows point to two (of numerous) nonpigmented melanoma cells, and arrowheads point to two pigmented melanoma cells.
