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. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: Dig Dis Sci. 2014 Jul 17;59(12):2874–2889. doi: 10.1007/s10620-014-3277-1

Table 3. Studies of serrated polyps and smoking.

Author, year Study description n with SPs Smoking* OR/RR† (95% CI)
All SPs
Kearney, 1995 [44] US population (NHS/HPFS) Screening sigmoidoscopy or colonoscopy, distal HP/SP only 394 graphic file with name nihms780724t7.jpg
graphic file with name nihms780724t8.jpg
Martinez, 1997 [41] US population (TX) Screening sigmoidoscopy or colonoscopy 81 graphic file with name nihms780724t9.jpg
Erhardt, 2002 [42] German population Screening/diagnostic colonoscopy 71 Ever smoker: 1.79 (1.04-3.06)
Morimoto, 2002 [45] US population (MN) Screening/diagnostic colonoscopy 219 Former smoker: 2.5 (1.4-4.4)
Current smoker: 4.1 (2.2-7.6)
Lieberman, 2003 [33] US population (veterans) Screening colonoscopy 391 Former smoker: 1.65 (1.23-2.23)
Current smoker: 2.71 (1.93-3.81)
Ji, 2006 [43] US population (PLCO) Screening sigmoidoscopy, distal HP/SP only 1545 Former smoker: 1.8 (1.6-2.1)
Current smoker: 4.4 (3.7-5.2)
Ever smoker: 2.1 (1.9-2.4)
Omata, 2009 [46] Japanese population Diagnostic colonoscopy 132 graphic file with name nihms780724t10.jpg
Fu, 2012 [60] US population (TN) Screening/diagnostic colonoscopy 662 Former smoker: 1.93 (1.56-2.38)
Current smoker: 4.44 (3.47-5.67)
<30 pack-years: 4.74 (3.51-6.42)
≥30 pack-years: 4.04 (3.02-5.42)
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Screening colonoscopy 594 Former smoker: 1.70 (1.34-2.16)
Current smoker: 3.00 (1.93-4.66)
Proximal/large SPs
Wallace, 2009 [52] US population (multicenter/PPSG) Proximal SPs 261 Former smoker: 0.98 (0.75-1.28)
Current smoker: 1.11 (0.80-1.54)
Bouwens, 2013 [51] Dutch population Proximal, large (>6mm) or dysplastic SPs 141 graphic file with name nihms780724t11.jpg
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Proximal SPs 199 Former smoker: 1.16 (0.79-1.71)
Current smoker: 0.88 (0.32-2.39)
SSAs
Anderson, 2011 [49] US population (CT) Pancolonic SSAs 90 graphic file with name nihms780724t12.jpg
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Pancolonic SSAs 149 graphic file with name nihms780724t13.jpg
*

Referent category (OR/RR=1.0) is nonsmokers or never smokers for all studies unless otherwise stated

†

multivariate adjusted OR reported when provided

SP: serrated polyp; SSA: sessile serrated adenoma; OR: odds ratio; RR: risk ratio; CI: confidence interval; NHS/HPFS: Nurses Health Study/Health Professionals Followup Study; PLCO: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; PPSG: Polyp Prevention study Group

Red text: statistically significant result