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. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: Dig Dis Sci. 2014 Jul 17;59(12):2874–2889. doi: 10.1007/s10620-014-3277-1

Table 5. Studies of serrated polyps and nonsteroidal anti-inflammatory drug (NSAID) or aspirin usage.

Author, year Study description n with SPs NSAID/ASA OR/RR* (95% CI)
All SPs
Martinez, 1997 [41] US population (TX) Screening sigmoidoscopy or colonoscopy 81 graphic file with name nihms780724t18.jpg
Morimoto, 2002 [45] US population (MN) Screening/diagnostic colonoscopy 219 Never use: 1.0 [ref]
≥once/week aspirin: 1.0 (0.6-1.6)
≥once/week NSAID: 0.6 (0.3-1.1)
Lieberman, 2003 [33] US population (veterans) Screening colonoscopy 391 graphic file with name nihms780724t19.jpg
Fu, 2012 [60] US population (TN) Screening/diagnostic colonoscopy 662 Never use: 1.00 [ref]
Former use: 0.96 (0.68-1.35)
Current Use: 0.84 (0.69-1.01)
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Screening colonoscopy 594 Nonuse: 1.00 [ref]
Former use: 0.89 (0.59-1.33)
Current use: 0.81 (0.64-1.03)
Proximal/large SPs
Wallace, 2009 [52] US population (multicenter/PPSG) Proximal SPs 261 graphic file with name nihms780724t20.jpg
Bouwens, 2013 [51] Dutch population Proximal, large (>6mm) or dysplastic SPs 141 graphic file with name nihms780724t21.jpg
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Proximal SPs 199 Nonuse: 1.00 [ref]
Former use: 1.21 (0.67-2.19)
Current use: 0.68 (0.46-1.03)
SSAs
Burnett-Hartman, 2013 [48] US population (Group Health, WA) Pancolonic SSAs 149 Nonuse: 1.00 [ref]
Former use: 1.39 (0.75-2.56)
Current use: 0.64 (0.41-1.01)
*

multivariate adjusted OR reported when provided

SP: serrated polyp; SSA: sessile serrated adenoma; BMI: body mass index; OR: odds ratio; RR: risk ratio; CI: confidence interval; PPSG: Polyp Prevention study Group

Red text: statistically significant result