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. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: Biol Psychiatry. 2010 Oct 29;69(1):80–89. doi: 10.1016/j.biopsych.2010.08.022

Figure 1.

Figure 1

Overview of methodology. (I) The tractographic maps show the set of all cortico-cortical streamlines (normalized to Montreal Neurological Institute space). II. Connectivity matrices were populated and (III) binarized, where matrix element (i,j) quantifies the connectivity (i.e., number of interconnecting streamlines) between node pair (i,j). The rows/columns of the connectivity matrix and the binarized connectivity matrix were ordered such that all left hemisphere nodes occupied the first 41 rows/columns. Hence, the two strongly interconnected sub-blocks along the matrix diagonal exclusively involve intrahemispheric connections, whereas the two off-diagonal sub-blocks involve interhemispheric connections. Note the strong contralateral connection profile indicated by the connections along the main diagonal of each interhemispheric sub-block. All matrices represent group averages. (IV) The network-based statistic (Methods and Materials) was used to identify impaired connections.