Figure 2. Fancc is Required for Host Defense against SIN and HSV-1 CNS Viral infections.
(A) Survival of 7 day-old mice infected intracerebrally (i.c.) with 1000 PFUs SIN strain dsTE12Q. Results shown represent combined survival for independent infections of more than 5 litters (similar results obtained for each infection). P-value (log-rank test) and number of mice per genotype indicated in graph.
(B and C) Quantitation of TUNEL-positive area per brain section (B) and representative light micrographs (C) after infection of 7 day-old mice of indicated genotype infected as in (A). Bars represent median value for each group. *, P<0.05; Mann-Whitney U test. Scale bars, 500 μm.
(D) Survival of 6-8 week-old mice infected i.c. with 5x104 PFUs HSV-1 ICP34.5Δ68-87. Results shown represent combined survival data combined from three independent infections (similar results obtained for each infection). P-value (log-rank test) and number of mice per genotype indicated in graph.
(E and F) Quantitation of TUNEL-positive area per brain section (E) and representative light micrographs (F) at indicated time points of 2 month-old mice infected as in (D). Bars represent median value for each group. **, P<0.01; Mann-Whitney U test. Scale bars, 500 μm.
See also Figure S2.