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. 2016 Jun;105:618–629. doi: 10.1016/j.neuropharm.2016.02.028

Fig. 3.

Fig. 3

α7 nAChR activation but not positive allosteric modulation directly depolarises layer V inhibitory interneurons. Changes in the membrane potential of layer V non-fast spiking (NFS) and fast spiking (FS) inhibitory interneurons were recorded in response to α7 nAChR modulation activation and inhibition. A. Spiking profile of layer V NFS (left) and FS (right) interneurons in response to a 300 ms current injection of +150 pA or −150 pA. Scale bars 50 mV and 100 ms. B. Representative current clamp recording from NFS (left) and FS (right) showing the changes in membrane potential in response to 10 μM PNU-120596 (‘PNU 1’), co-application of PNU-120596 and 300 nMPNU-282987 (‘PNU1 + PNU 2’), and addition of 100 nM MLA. C. Averaged membrane potential in response to 10 μM PNU-120596 in NFS (left; n = 3) and FS (right; n = 5) interneurons; recordings from 3 animals (C), and in response to co-application of PNU-120596 and 300 nM PNU-282987 followed by addition of 100 nM MLA in NFS (left; n = 5) and FS (right; n = 5); recordings from 3 animals (D). * significantly different from control, p ≤ 0.05, one-way repeated measures ANOVA with Dunnett's post hoc test.