Fig. 6.

Both antagonism and activation of α7 nAChRs decreases evoked EPSC amplitudes. EPSCs were evoked in layer V pyramidal neurons by stimulation of distal dendrites in layers II/III of the prelimbic cortex. The amplitude of these EPSCs was measured before and after bath application of (A) MLA (100 nM), n = 4 (4), (B) co-application of the α7 nAChR PAM PNU-120596; (10 μM) and α7 nAChR agonist PNU-282987 (300 nM), n = 5 (5), and (C) α7 nAChR 10 μM PAM alone, n = 4 (4). Time-courses show amplitude of evoked potentials as a % of mean control potentials that were collected for 20 min in the absence of drugs; histograms show averaged data at time points 10 min (control) and 40 min (drug). * significantly different from control, p ≤ 0.05, paired t-test.