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. 2016 Apr 25;17(5):615. doi: 10.3390/ijms17050615

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The protective effect of TNFSF15 on diabetes induced BRB permeability. (A) Quantitative measurement of the BRB permeability by quantification of extravasated EB. Data are presented as percentage of controls (six eyes). * p < 0.001, compared with the control group; ** p < 0.001, compared with the DM group; NS = nonsignificance; (B) Representative images showing EB fluorescence. In the retina of control rats, EB fluorescence is limited to the blood vessels, whereas in diabetic retina, the dye leaks out of the vessels to the retinal tissue (arrows). TNFSF15 treatment prevents the leakage of EB. Magnification 400×.