Table 2.
Top pathways enriched in the differentially expressed proteins—results from DAVID (Database for Annotation, Visualization, and Integrated Discovery). NS: non-significant.
| Pathway | Database | HV/CKD1-2 | HV/CKD5 | HV/CVD | Benjamini Corrected p-Value |
|---|---|---|---|---|---|
| (% of Whole Proteins) | (% of Whole Proteins) | (% of Whole Proteins) | |||
| Hemostasis | REACTOME | 23.8 | 19.7 | 23.3 | 3.1 × 10−6/4.2 × 10−7/9.6 × 10−6 |
| Complement cascade | KEGG | 23.9 | 13.6 | 9.3 | 3.6 × 10−11/4.1 × 10−8/4.5 × 10−2 |
| Blood coagulation | PANTHER | 17.5 | 25 | 13.7 | 1.2 × 10−1/5.7 × 10−12/1.8 × 10−7 |
| Inflammation mediated by chemokine and cytokine signaling pathway | PANTHER | 8.3 | 8.3 | 4.8 | 2.5 × 10−5/6.4 × 10−5/2.4 × 10−6 |
| Integrin cell surface interaction | REACTOME | 15.2 | 12.1 | – | 1.1 × 10−4/1.5 × 10−6/NS |
| Signaling in immune system | REACTOME | 12.1 | 19.6 | – | 2.8 × 10−3/2.5 × 10−3/NS |
| Plasminogen activation cascade | PANTHER | 7.6 | 10.9 | – | 5.6 × 10−5/7.1 × 10−5/NS |
| Cardiac muscle contraction | KEGG | – | – | 9.3 | NS/NS/3.2 × 10−2 |
| Cardiomyopathy | KEGG | – | – | 14.6 | NS/NS/2.7 × 10−2 |
| Metabolism of lipids and lipoproteins | PANTHER | 8.3 | 3.1 | 8.3 | 2.4 × 10−4/2.1 × 10−3/2.8 × 10−5 |