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. 2016 Apr 29;17(5):635. doi: 10.3390/ijms17050635

Figure 3.

Figure 3

Effects of NaHS on the lipid metabolism of high-fat dieted ApoE−/− mice. Six-week-old ApoE−/− mice fed a high-cholesterol diet were dosed daily with NaHS (50 μM/kg/day, intraperitoneally), pravastatin (30 mg/kg/day, intragastrically), or vehicle (saline solution) for 14 weeks. (A) Serum was reserved for detecting total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C, n = 10, *** p < 0.001 vs. control; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. vehicle); (B) Representative images of Oil Red O-stained aortas; (C) Quantization of lesion areas in Oil Red O-stained aortas (n = 10, *** p < 0.001 vs. control; # p < 0.05, ## p < 0.01 vs. vehicle); (D) Livers were collected from each group. Equal amount of proteins from liver lysates of each mouse in the same group were pooled and subjected to Western blotting for ABCA1 expression. Tubulin was used as a control (n = 10, ** p < 0.01, *** p < 0.001 vs. vehicle).