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. 2016 May 3;17(5):665. doi: 10.3390/ijms17050665

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Significantly-altered circulating miRNAs (fold-change >2; p < 0.05) at individual time points during disease progression at hyperinsulinemia (HI), β cell failure (BCF) and late-stage diabetes (LSD) analyzed by qRT-PCR. Log₂-fold changes of increased or decreased miRNA species at HI, BCF and LSD are indicated. Each time point was compared to the baseline (week 6 of age).