Table 3.
Enriched KEGG pathways for predicted targets of the DD/DDR microRNAs modulated by all four compounds.
| KEGG Pathway | p-Value | #of Genes | miRNAs |
|---|---|---|---|
| Fatty acid biosynthesis | 0 | 4 | miR-16 |
| Fatty acid metabolism | 2.23 × 10-5 | 7 | miR-16 |
| Thyroid hormone synthesis | 2.58 × 10-5 | 5 | miR-146b |
| Signaling pathways regulating pluripotency of stem cells | 0.0002346931 | 24 | miR-16 |
| Glioma | 0.000556152 | 15 | miR-16 miR-34a |
| Glycosphingolipid biosynthesis: lacto and neolacto series | 0.001440903 | 2 | miR-34a |
| Hippo signaling pathway | 0.00410767 | 24 | miR-16 miR-21 |
| Steroid hormone biosynthesis | 0.009497578 | 1 | miR-25 |
| Ovarian steroidogenesis | 0.01398717 | 1 | miR-25 |
| Melanoma | 0.01891852 | 14 | miR-16 |
| Prostate cancer | 0.02681897 | 16 | miR-16 |
| Cytokine-cytokine receptor interaction | 0.03260184 | 11 | miR-21 |
| mTOR signaling pathway | 0.03417768 | 13 | miR-16 miR-25 |
| Oocyte meiosis | 0.03995201 | 16 | miR-16 |
DIANA-miRPath v3.0 [66] was used to predict the targeted KEGG pathways by miRs involved in DD/DDR signaling and modulated by all considered compounds (EGCG, CRC, RSV and n3-PUFAs). The target prediction threshold was set at 0.85. p-value < 0.05. #: number.