Figure 2.

Developmental disorders in epithelial cell–specific Ppp2ca knockout mice. (A) Change trend curve of the body weight of Ppp2ca^flox/flox; Krt14-Cre mouse and littermate control groups. n = 6 animals/genotype; (B) Body weight of eight-week Ppp2ca^flox/flox; Krt14-Cre mouse and littermate control group. n = 3 in each group, *** p < 0.001; (C) Paw pigmentation at different weeks of Ppp2ca^flox/flox; Krt14-Cre and littermate control group. Base of the claws in the mutant mice and the control group at one to six weeks; (D) Tail of normal (left) and mutant (right) mice at eight weeks. Ppp2ca^flox/flox; Krt14-Cre mice have a smaller body and exhibit hair loss compared to the littermate control group; (E) Claws on bottom of normal (left) and mutant (right) mice at eight weeks; (F) Ppp2ca^flox/flox; Krt14-Cre mice exhibit anal plug and bowel problems.