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. 2016 May 18;17(5):759. doi: 10.3390/ijms17050759

Figure 3.

Figure 3

Model of DNA methylation and histone methylation regulating gene expression for breast and ovarian cancer initiation. (A,B) Hypermethylation is indicated by red balls (CpG residue). White balls represent unmethylated CpG residues. DNMT1 represents DNA methyl transferase 1, POLII represents RNA polymares II; (B) In the absence of hypermethylation, POLII is able to bind to the promoter region and initiate transcription; (C,D) White balls represent unmethylated, and red balls represent hypermethylated CpG residues. CCCTC is CTCF binding motif. The green circle represents effective insulation zone. Break of insulated zone is shown by dotted green circle.