Table 2.
miRNA implicated in breast and ovarian cancers.
| miRNA | Up-/Downregulated | Gene Target | Gene Activity | Breast Cancer? | Ovarian Cancer? | Function |
|---|---|---|---|---|---|---|
| miR-100 [29] | Down | FRAP1/mTOR, FGFR3 [30] | - | Yes | Yes | Cell growth and survival |
| miR-9 [31] | Down | FGF18, FGF10, BCL2, BCL6, BRAF, CLDN14, CLDN6, SEPTIN10, ZNF, PVRL2, LASS4, BCL2, CLDN, FGF | - | Yes (miR-9-3) | Yes | Drug resistance |
| miR-214 [29,32] | Down | PTEN, EZH2 | Suppression | Yes | Yes | Cell survival, cisplatin resistance, Akt |
| miR-125a [33] | Down | HER2, ARI3B | Suppression | Yes | Yes | EMT |
| miR-125b [33] | Down | HER2 | Suppression | Yes | Yes | EMT |
| miR-22 [34,35] | - | miR-20 | - | Yes | - | Metastasis |
| miR-34c [36] | Down | - | - | - | - | EMT |
| miR-199a [37] | Down | - | - | - | Yes | |
| miR-200a [38] | Down(EMT)/Up(MET) | ZEB2 | Suppression | - | Yes | EMT |
| miR-200c [38] | Down(EMT)/Up(MET) | ZEB1/2 | Suppression | - | Yes | EMT |
| miR-146a | Up (variant allele) | BRCA1/2 | - | - | Yes | - |
| miR-210 [39] | Down (CNA) | E2F3 (TxF) | - | - | Yes | HIF |
| miR-233 [40] | Up | FGFR2, EGF, S100A3, KRAS, TGFΒ2, IFNBI, SPINKS, E2F1, SEPTIN6, MMP9, USF2 | - | - | - | Ras, integrin signal |
| miR-206 [33,41] | Up | ERα | Suppression | Yes | - | - |