Table 1.
PD-L1 (programmed death ligand 1) immunohistochemical (IHC) staining criteria for each tumor type.
| Tumor Type | Percentage pf PD-L1 Positive Tumor Cells | PD-L1 Intensity of Reaction | PD-L1 Complete Membrane Positivity | PD-L1 Incomplete Membrane Positivity | PD-L1 Cytoplasmic Positivity |
|---|---|---|---|---|---|
| Breast cancer | 60% | Moderate/Intense | + | + | +/− |
| Ovarian cancer | <10% | Moderate | − | + | +/− |
| Thyroid cancer | <10% | Mild | + | + | − |
| Colon cancer | <10% | Moderate | + | + | − |
| Lung cancer | 10% | Moderate | + | + | + |
| Kidney cancer | 20% | Moderate | + | − | +/− |
| Melanoma | 60% | Moderate/Intense | + | + | +/− |
| Sarcoma | 50% | Moderate | + | + | +/− |
| Non-Hodgkin lymphoma | 60% | Moderate/Intense | + | + | − |