Table 1.

cLogP and t_1/2 of silicated paclitaxel prodrugs with different alkyl groups.

2′-O	7-O	cLogP	T1/2 (min)
H	H	3.2	N/A
Si(OEt)3	H	5.0	3.7
Si(On-Oct)3	H	7.7	12
Si(Oi-Pr)	H	5.6	120
Si(Ot-Bu)2(OEt)	H	5.8	12,000
Si(Omenthyl)3	H	7.4	69,000
H	Si(OEt)3	5.1	30
H	Si(On-Oct)3	7.8	150
Si(OEt)3	Si(OEt)3	6.3	4.6 (2′-O) 33 (7-O)