Table 1.

Review of percutaneous mitral valve repair trials

Trials	Method	Efficacy	Safety
EVEREST	Single arm study to evaluate the feasibility and safety of mitral clip (n=107)	66% met the composite end-point of improved MR, freedom from cardiac surgery and freedom from death	104 were discharged home 5 patients had bleeding, 3 had atrial septal complications
EVEREST II	279 patients with moderately severe to severe MR (almost half functional) randomized 2:1 percutaneous repair vs. conventional surgery	Effective at reducing MR Lower 30 days mortality Long durability up to 24 months Improved quality of live More frequent additional procedures	Less adverse events and Less blood transfusion in the mitral clip arm
TITAN	The impact of mitral annuloplasty on functional MR in 36 patients	Improvement in 6MWD and Kansas City Cardiomyopathy Questionnaire Improvement in LV geometry	No device related complications reported

MR: Mitral regurgitation, LV: Left ventricular