TABLE 2.
Clinical Characteristics of MrOS Sleep Participants by CKD-EPIcr,cysc eGFR Category
| CKD-EPIcr,cysc eGFR category (mL/min/1.73m2)
|
||||||
|---|---|---|---|---|---|---|
| Baseline Characteristics | Overall (N= 2994) |
≥75 (N= 1205) |
60 to 74 (N= 939) |
45 to 59 (N= 602) |
<45 (N= 248) |
P-value |
| Age, years, mean (SD) | 76.4 (5.6) | 74.3 (4.7) | 76.5 (5.1) | 79.0 (5.7) | 80.0 (6.1) | <0.001 |
| Race/Ethnicity, n (%) | <0.001 | |||||
| White | 2696 (90) | 1048 (87) | 867 (92) | 556 (92) | 225 (91) | |
| Black | 109 (4) | 58 (5) | 26 (3) | 20 (3) | 5 (2) | |
| Other | 189 (6) | 99 (8) | 46 (5) | 26 (4) | 18 (7) | |
| Education, n (%) | <0.001 | |||||
| Less than high school | 160 (5) | 52 (4) | 41 (4) | 41 (7) | 26 (10) | |
| High school | 472 (16) | 162 (13) | 148 (16) | 122 (20) | 40 (16) | |
| College/grad school | 2362 (79) | 991 (82) | 750 (80) | 439 (73) | 182 (73) | |
| Body mass index, kg/m2, mean (SD) | 27.2 (3.8) | 26.8 (4) | 27.4 (3.8) | 27.4 (3.9) | 27.8 (4.3) | <0.001 |
| Appendicular lean mass, kg, mean (SD) | 23.9 (3.5) | 24.1 (3.4) | 24.1 (3.4) | 23.7 (3.6) | 23.2 (3.5) | <0.001 |
| Total body lean mass, kg, mean (SD) | 56.3 (7.1) | 56.4 (7.0) | 56.8 (7.1) | 55.9 (7.3) | 55.4 (7.3) | 0.01 |
| Smoking, n (%) | 0.13 | |||||
| Never | 1183 (40) | 473 (39) | 387 (41) | 233 (39) | 90 (36) | |
| Past | 1750 (58) | 712 (59) | 535 (57) | 348 (58) | 155 (63) | |
| Current | 59 (2) | 20 (2) | 16 (2) | 20 (3) | 3 (1) | |
| Self-rated health good/excellent, n (%) | 2596 (87) | 1086 (90) | 826 (88) | 491 (82) | 193 (78) | <0.001 |
| Hypertension*, n (%) | 1894 (63) | 617 (51) | 584 (62) | 465 (77) | 228 (92) | <0.001 |
| Diabetes mellitus*, n (%) | 402 (13) | 140 (12) | 117 (12) | 88 (15) | 57 (23) | <0.001 |
| Self-reported stroke, n (%) | 110 (4) | 34 (3) | 32 (3) | 23 (4) | 21 (8) | <0.001 |
| Self-reported coronary heart disease**, n (%) | 765 (26) | 236 (20) | 225 (24) | 196 (33) | 108 (44) | <0.001 |
| Self-reported congestive heart failure, n (%) | 181 (6) | 37 (3) | 43 (5) | 56 (9) | 45 (18) | <0.001 |
| Self-reported peripheral vascular disease, n (%) | 291 (10) | 80 (7) | 74 (8) | 84 (14) | 53 (22) | <0.001 |
| Alcohol intake, drinks/week, n (%) | <0.001 | |||||
| 0–2 | 1761 (59) | 638 (53) | 552 (59) | 386 (65) | 185 (75) | |
| 3–13 | 1048 (35) | 473 (39) | 333 (36) | 189 (32) | 53 (21) | |
| ≥14 | 168 (6) | 87 (7) | 49 (5) | 23 (4) | 9 (4) | |
| CKD-EPIcr,cys eGFR, mean (SD) | 69.8 (17.1) | 86.3 (8.0) | 67.9 (4.3) | 53.5 (4.2) | 37 (7.0) | <0.001 |
| BIS2 eGFR, mean (SD) | 62.4 (13.6) | 75.3 (7.7) | 60.6 (3.5) | 49.8 (3.4) | 37.2 (5.9) | <0.001 |
| CKD-EPIcys eGFR, mean (SD) | 67.8 (19.8) | 86.6 (11.6) | 64.4 (7.8) | 49.6 (6.3) | 34.0 (7.3) | <0.001 |
| CKD-EPIcr eGFR, mean (SD) | 70.7 (14.9) | 82.9 (7.4) | 70.8 (7.9) | 58.1 (7.3) | 41.3 (8.7) | <.001 |
| Follow up time, years, mean (SD) | 7.3 (1.9) | 7.6 (1.6) | 7.4 (1.9) | 6.9 (2.2) | 6.1 (2.5) | <0.001 |
Abbreviations: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin c; eGFR, estimated glomerular filtration rate; BIS2, Berlin Initiative Study Equation 2
*
As determined by self-report or any disease-specific medication use
**
Coronary heart disease includes myocardial infarction, coronary artery bypass grafting, and angioplasty