TABLE 3.
Association of eGFR and All-Cause Mortality
| Relative Hazard (95% Confidence Interval)
|
||||
|---|---|---|---|---|
| Estimating Equation Category (mL/min/1.73m2) |
Age Adjusted Incidence Rate per 1,000 Person Years (95% CI) |
Unadjusted | Base Model* | Final Model** |
| CKD-EPIcr,cysc | ||||
| ≥75 | 26.94 (22.93, 30.96) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 33.28 (28.11, 38.45) | 1.51 (1.25, 1.83) | 1.21 (1.00, 1.47) | 1.20 (0.98, 1.46) |
| 45 to 59 | 38.18 (31.97, 44.38) | 2.24 (1.84, 2.73) | 1.38 (1.12, 1.70) | 1.31 (1.06, 1.62) |
| <45 | 75.19 (56.63, 93.75) | 4.43 (3.56, 5.52) | 2.47 (1.95, 3.14) | 2.08 (1.62, 2.66) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
| BIS2 | ||||
| ≥75 | 26.54 (18.48, 34.61) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 28.89 (24.42, 33.35) | 1.45 (1.11, 1.89) | 1.08 (0.83, 1.42) | 1.10 (0.84, 1.43) |
| 45 to 59 | 35.98 (31.29, 40.66) | 2.39 (1.84, 3.10) | 1.32 (1.00, 1.74) | 1.27 (0.96, 1.68) |
| <45 | 69.67 (55.40, 83.93) | 5.31 (4.03, 7.00) | 2.37 (1.75, 3.22) | 2.05 (1.50, 2.79) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
| CKD-EPIcr | ||||
| ≥75 | 34.28 (26.41, 42.15) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 33.21 (28.55, 37.88) | 1.28 (1.08, 1.53) | 1.03 (0.86, 1.23) | 1.02 (0.85, 1.22) |
| 45 to 59 | 37.15 (30.81, 43.49) | 1.71 (1.41, 2.08) | 1.15 (0.93, 1.4) | 1.05 (0.85, 1.28) |
| <45 | 78.79 (48.58, 108.97) | 3.25 (2.55, 4.14) | 1.78 (1.38, 2.29) | 1.53 (1.18, 1.99) |
| p-trend | – | <0.001 | <0.001 | 0.019 |
| CKD-EPIcysc | ||||
| ≥75 | 27.52 (22.84, 32.21) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 31.39 (25.96, 36.81) | 1.43 (1.16, 1.77) | 1.14 (0.92, 1.41) | 1.12 (0.90, 1.39) |
| 45 to 59 | 34.01 (28.74, 39.29) | 1.92 (1.56, 2.37) | 1.26 (1.01, 1.56) | 1.21 (0.97, 1.51) |
| <45 | 71.52 (58.76, 84.23) | 4.54 (3.70, 5.56) | 2.45 (1.96, 3.07) | 2.14 (1.70, 2.71) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
Abbreviations: eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin c; BIS, Berlin Initiative Study
*
adjusted for age, race/ethnicity, and body mass index
**
adjusted for age, race/ethnicity, body mass index, hypertension, diabetes mellitus, congestive heart failure, coronary heart disease, and stroke