Appendix Table 4.
Clinical Characteristics of MrOS Sleep Participants by CKD-EPIcr eGFR Category
| CKD-EPIcr eGFR category (mL/min/1.73m2)
|
||||||
|---|---|---|---|---|---|---|
| Baseline Characteristics | Overall (N= 2994) |
≥75 (N= 1320) |
60 to 74 (N= 978) |
45 to 59 (N= 522) |
<45 (N= 174) |
P-value |
| Age, years, mean (SD) | 76.4 (5.6) | 74.7 (4.9) | 76.9 (5.3) | 78.5 (5.7) | 80.1 (6.1) | <.001 |
| Race/Ethnicity, n (%) | 0.10 | |||||
| White | 2696 (90) | 1174 (89) | 890 (91) | 478 (92) | 154 (89) | |
| Black | 109 (4) | 62 (5) | 28 (3) | 15 (3) | 4 (2) | |
| Other | 189 (6) | 84 (6) | 60 (6) | 29 (6) | 16 (9) | |
| Education, n (%) | 0.01 | |||||
| Less than high school | 160 (5) | 64 (5) | 44 (5) | 34 (7) | 18 (10) | |
| High school | 472 (16) | 198 (15) | 157 (16) | 95 (18) | 22 (13) | |
| College/grad school | 2362 (79) | 1058 (80) | 777 (79) | 393 (75) | 134 (77) | |
| Body mass index, kg/m2, mean (SD) | 27.2 (3.8) | 27.1 (4.0) | 27.1 (3.6) | 27.3 (3.9) | 27.5 (4.0) | 0.56 |
| Appendicular lean mass, kg, mean (SD) | 23.9 (3.5) | 24.0 (3.5) | 24.1 (3.3) | 23.9 (3.6) | 23.1 (3.3) | 0.007 |
| Total body lean mass, kg, mean (SD) | 56.3 (7.1) | 56.3 (7.2) | 56.6 (7.0) | 56.2 (7.2) | 55.1 (7.1) | 0.07 |
| Smoking, n (%) | 0.08 | |||||
| Never | 1183 (40) | 495 (38) | 424 (43) | 196 (38) | 68 (39) | |
| Past | 1750 (58) | 794 (60) | 537 (55) | 314 (60) | 105 (60) | |
| Current | 59 (2) | 30 (2) | 17 (2) | 11 (2) | 1 (1) | |
| Self-rated health good/excellent, n (%) | 2596 (87) | 1164 (88) | 860 (88) | 436 (84) | 136 (78) | <.001 |
| Hypertension*, n (%) | 1894 (63) | 710 (54) | 614 (63) | 412 (79) | 158 (91) | <.001 |
| Diabetes mellitus*, n (%) | 402 (13) | 161 (12) | 110 (11) | 91 (17) | 40 (23) | <.001 |
| Self-reported stroke, n (%) | 110 (4) | 39 (3) | 34 (3) | 21 (4) | 16 (9) | <.001 |
| Self-reported coronary heart disease**, n (%) | 765 (26) | 279 (21) | 251 (26) | 170 (33) | 65 (38) | <.001 |
| Self-reported congestive heart failure, n (%) | 181 (6) | 52 (4) | 46 (5) | 53 (10) | 30 (17) | <.001 |
| Self-reported peripheral vascular disease, n (%) | 291 (10) | 94 (7) | 92 (10) | 70 (14) | 35 (21) | <.001 |
| Alcohol intake, drinks/week, n (%) | <.001 | |||||
| 0–2 | 1761 (59) | 736 (56) | 578 (60) | 317 (61) | 130 (75) | |
| 3–13 | 1048 (35) | 486 (37) | 346 (36) | 179 (34) | 37 (21) | |
| ≥14 | 168 (6) | 92 (7) | 47 (5) | 23 (4) | 6 (3) | |
| CKD-EPIcr,cys eGFR, mean (SD) | 69.8 (17.1) | 83.4 (10.4) | 67.0 (8.6) | 52.3 (7.8) | 35.6 (8.2) | <.001 |
| BIS2 eGFR, mean (SD) | 62.4 (13.6) | 72.9 (9.3) | 59.9 (7.0) | 49.3 (6.7) | 36.3 (7.1) | <.001 |
| CKD-EPIcys eGFR, mean (SD) | 67.8 (19.8) | 80.6 (15.6) | 65.3 (14.2) | 51.2 (12.7) | 34.9 (10.4) | <.001 |
| CKD-EPIcr eGFR, mean (SD) | 70.7 (14.9) | 84.0 (5.7) | 67.9 (4.3) | 53.6 (4.2) | 37.2 (7.2) | <.001 |
| Follow up time, years, mean (SD) | 7.3 (1.9) | 7.5 (1.7) | 7.3 (1.9) | 7.0 (2.1) | 6.3 (2.5) | <.001 |
Abbreviations: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin c; eGFR, estimated glomerular filtration rate; BIS2, Berlin Initiative Study Equation 2
*
As determined by self-report or any disease-specific medication use
**
Coronary heart disease includes myocardial infarction, coronary artery bypass grafting, and angioplasty