Appendix Table 6.
Association of eGFR and Cardiovascular Mortality
| Estimating Equation, Category (mL/min/1.73 m2) | Age Adjusted Incidence Rate per 1000 person years (95% CI) | Relative Hazard (95% Confidence Interval) | ||
|---|---|---|---|---|
| Unadjusted | Base Model* | Final Model** | ||
| CKD-EPIcr, cysc | ||||
| ≥75 | 9.22 (6.81, 11.63) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 10.07 (6.94, 13.21) | 1.37 (0.97, 1.93) | 1.06 (0.74, 1.50) | 1.03 (0.72, 1.46) |
| 45 to 59 | 12.57 (9.07, 16.07) | 2.34 (1.66, 3.30) | 1.36 (0.94, 1.96) | 1.16 (0.80, 1.68) |
| <45 | 29.20 (20.65, 37.75) | 6.20 (4.36, 8.81) | 3.16 (2.15, 4.64) | 2.24 (1.51, 3.33) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
| BIS2 | ||||
| ≥75 | 8.85 (3.69, 14.01) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 9.01 (6.81, 11.210) | 1.44 (0.90, 2.30) | 1.02 (0.63, 1.64) | 1.05 (0.64, 1.70) |
| 45 to 59 | 11.96 (9.21, 4.72) | 2.46 (1.56, 3.89) | 1.24 (0.76, 2.01) | 1.13 (0.69, 1.85) |
| <45 | 25.64 (17.85, 33.42) | 7.08 (4.42, 11.34) | 2.79 (1.66, 4.68) | 2.05 (1.21, 3.47) |
| p-trend | – | <0.001 | <0.001 | 0.001 |
| CKD-EPIcr | ||||
| ≥75 | 9.16 (7.01, 11.31) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 11.38 (8.84, 13.92) | 1.48 (1.09, 2.02) | 1.17 (0.86, 1.61) | 1.15 (0.84, 1.57) |
| 45 to 59 | 12.42 (8.70, 16.13) | 1.91 (1.35, 2.71) | 1.23 (0.86, 1.77) | 1.01 (0.70, 1.45) |
| <45 | 28.26 (18.16, 38.35) | 5.40 (3.71, 7.84) | 2.81 (1.89, 4.19) | 2.18 (1.46, 3.26) |
| p-trend | – | <0.001 | <0.001 | 0.008 |
| CKD-EPIcysc | ||||
| ≥75 | 9.29 (6.30, 12.28) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| 60 to 74 | 10.19 (6.93, 13.45) | 1.53 (1.05, 2.23) | 1.15 (0.78, 1.68) | 1.10 (0.74, 1.62) |
| 45 to 59 | 10.79 (7.80, 13.77) | 2.01 (1.38, 2.91) | 1.22 (0.83, 1.81) | 1.08 (0.73, 1.60) |
| <45 | 27.00 (19.58, 34.42) | 6.24 (4.42, 8.82) | 3.04 (2.07, 4.46) | 2.20 (1.49, 3.27) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
Abbreviations: eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin c; BIS, Berlin Initiative Study
*
adjusted for age, race, and body mass index
†
adjusted for age, race, body mass index, hypertension, diabetes mellitus, congestive heart failure, coronary heart disease, and stroke