Appendix Table 7.
Association of eGFR and All-cause Mortality by Quartile of eGFR
| Relative Hazard (95% Confidence Interval)
|
||||
|---|---|---|---|---|
| Estimating Equation Category (mL/min/1.73m2) |
Age Adjusted Incidence Rate per 1,000 Person Years (95% CI) |
Unadjusted | Base Model* | Final Model** |
| CKD-EPIcr, cysc | ||||
| Q4: ≥83 | 24.74 (19.57, 29.92) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| Q3:71 to <83 | 29.36 (23.91, 34.81) | 1.41 (1.10, 1.81) | 1.13 (0.88, 1.45) | 1.12 (0.87, 1.44) |
| Q2:58 to <71 | 35.97 (30.14, 41.80) | 1.94 (1.54, 2.45) | 1.32 (1.03, 1.68) | 1.29 (1.01, 1.64) |
| Q1:<58 | 48.03 (41.57, 54.50) | 3.33 (2.68, 4.15) | 1.78 (1.40, 2.26) | 1.61 (1.26, 2.05) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
| BIS2 | ||||
| Q4: ≥71 | 27.37 (20.38, 34.35) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| Q3:63 to <71 | 28.29 (23.58, 33.01) | 1.50 (1.17, 1.93) | 1.19 (0.92, 1.53) | 1.19 (0.92, 1.54) |
| Q2:53 to <63 | 33.44 (27.82, 39.07) | 1.91 (1.50, 2.43) | 1.28 (1.00, 1.64) | 1.25 (0.98, 1.61) |
| Q1:<53 | 50.76 (43.72, 57.79) | 3.78 (3.03, 4.72) | 1.90 (1.48, 2.43) | 1.71 (1.33, 2.20) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
| CKD-EPIcr | ||||
| Q4: ≥82 | 33.40 (25.94, 40.85) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| Q3: 73 to <82 | 30.81 (25.63, 36.00) | 1.23 (0.98, 1.55) | 0.86 (0.68, 1.09) | 0.84 (0.67, 1.07) |
| Q2:61 to <73 | 32.39 (27.63, 37.14) | 1.43 (1.15, 1.79) | 1.16 (0.92, 1.45) | 0.92 (0.73, 1.15) |
| Q1:<61 | 40.86 (35.42, 46.30) | 2.20 (1.79, 2.71) | 1.25 (0.82, 1.89) | 1.15 (0.75, 1.76) |
| p-trend | – | <0.001 | 0.047 | 0.36 |
| CKD-EPIcysc | ||||
| Q4:≥82 | 26.99 (20.47, 33.52) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
| Q3:67 to <82 | 29.37 (23.82, 34.91) | 1.39 (1.08, 1.79) | 1.15 (0.89, 1.48) | 1.14 (0.88, 1.47) |
| Q2:53 to <67 | 34.58 (28.90, 40.26) | 1.94 (1.53, 2.47) | 1.31 (1.02, 1.68) | 1.29 (1.00, 1.65) |
| Q1:<53 | 52.51 (45.62, 59.39) | 3.76 (3.01, 4.68) | 2.04 (1.60, 2.60) | 1.83 (1.43, 2.35) |
| p-trend | – | <0.001 | <0.001 | <0.001 |
Abbreviations: eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; cr, creatinine; cysc, cystatin c; BIS, Berlin Initiative Study
*
adjusted for age, race, and body mass index
**
adjusted for age, race, body mass index, hypertension, diabetes mellitus, congestive heart failure, coronary heart disease, and stroke