Skip to main content
. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: J Am Chem Soc. 2016 Feb 19;138(8):2592–2601. doi: 10.1021/jacs.5b10307

Fig 4.

Fig 4

Lipid A contributes to the thermodynamic stability of bacterial OMPs. The stability differences ΔΔGs of 24 bacterial OMPs in the asymmetric bacterial outer membrane (OM) and a symmetric model OM were determined. With ∣ ΔΔG ∣ > lkcal/mol as the cutoff (grey line), all except OmpA have higher stability in the asymmetric membrane than in the symmetric membrane using either the total transfer free energy of all lipid-facing TM residues (white bar), or the folding free energy of the TM region (red bar). Only 15 OMPs show higher stability in the asymmetric OM if the total single burial energy of all lipid-facing TM residues is used (blue bar).