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. 2015 Oct 20;4(10):e258. doi: 10.1038/mtna.2015.34

Figure 1.

Figure 1

Novel types of RNAs induced downregulation of VEGF mRNA expression as effectively as siRNA. (a) Structure of novel RNA interference agents. Both nkRNA and PnkRNA were prepared as single-stranded RNA oligomers that underwent self-annealing, as shown. P indicates a proline derivative. (b) 10, 50, 100, and 200 µg of NIRNA, nkRNA, and PnkRNA against VEGF were transfected into mouse endothelial cells. Twenty-four hours after transfection, VEGF expression in the culture medium was measured using a VEGF ELISA kit. siRNA, small interfering RNA; VEGF, vascular endothelial growth factor.