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. 2016 Mar 15;24(5):877–889. doi: 10.1038/mt.2016.32

Figure 4.

Figure 4

BDNF neuroprotective effect is mediated by TrkB receptor. Primary cortical neurons were cotransduced with lentivectors (shRNA-sc or shRNA-37) and HSV-1 amplicon vectors (HSV-LacZ or HSV-BDNF). (a) Cell viability assay of cultured neurons at 72 hours upon cotransduction shows significant difference in the presence of the BDNF neutralizing antibody or a control IgY antibody (20 µg/ml) added to the media. (b) Cell viability assay of cultured neurons at 72 hours upon cotransduction shows significant difference in the absence or presence of 50 nM of TrkB inhibitor K252a. Data represent mean values ± SEM from three independent experiments, **P ≤ 0.005.