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. 2016 Mar 22;24(5):946–955. doi: 10.1038/mt.2016.39

Figure 1.

Figure 1

Design of chemically modified single-stranded and unmodified single-stranded/double-stranded miR-34a mimics. (a) Sequences and chemical modifications for miR-34a mimics. Modifications: 2-fluoro (2'-F, green), 2'-O-methyl (2'-O-Me, blue), 2'-O-methoxyethyl (2'-O-MOE, orange), phosphorothioate (PS) linkage (s, black), 5'-phosphate (P, red), unmodified RNA (black). (b) Structure of modified nucleotides.