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. 2016 Feb 16;24(5):956–964. doi: 10.1038/mt.2016.6

Figure 6.

Figure 6

Study on oligonucleotide-based therapy strategy. Arrows represent the nanochannel electroporation (NEP) delivery in multiple delivery strategy. (a) MCL1 mRNA level change with either optimized multiple NEP strategy of low dosage (500 copies) and short interval (3 hours) treatment or single NEP of high-dosage (8,800 copies) treatment. (b) Cell viability with either multiple NEP of low dosage (500 copies) and short interval (3 hours) treatment or single NEP of high-dosage (8,800 copies) treatment. (c) MCL1 mRNA level change with either multiple NEP strategy of low dosage (500 copies) and long interval (6 hours) treatment or single NEP of high-dosage (8,800 copies) treatment. (d) Cell viability with either multiple NEP of low dosage (500 copies) and long interval (6 hours) treatment or single NEP of high-dosage (8,800 copies) treatment. (e) Validation of multiple NEP with long dosage and short interval in patient blasts. (f) Cell viability of patient blasts with respective treatment.