Fig 1. Flowchart of patient enrollment, treatment group allotment, and progression through the study period.

Abbreviations: PDT-hemoporfin, hemoporfin-mediated PDT; PDT-placebo, laser irradiation plus placebo. Denotations: ^aData from participants were included in the primary efficacy analysis, missing data were imputed as no improvement. ^bA different area of the targeted lesion was treated.