Fig 2. Dominant-negative effect of the T108P variant.

Oocytes were coinjected with both WT TASK-2 and T108P mutant mRNA at different ratios and currents recorded at the indicated extracellular pH. At a 1:1 (WT:T108P) ratio the currents were markedly reduced. The effect is dose-dependent with further reductions at a ratio of 1:5 (WT:T108P). Results shown are means ± s.e.m. (WT vs 1:1, P<0.01 at pH 7.4 and pH 9; 1:1 vs 1:5, P<0.05 at pH 7.4 and pH9; 1:5 vs T108P, not significant at pH 7.4 or pH9, one-way ANOVA, post-hoc Tukey HSD test; n = 9 for all conditions).