Table 1. Dark-adapted ERG (3.0 cd∙s/m2) Amplitudes from rd11 Mice at 4 Months after Treatment.
| rd11 mice | P-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Amplitude, μV | WT | P10 (A) | P14 (B) | P14 (C) | P18 (D) | P22 (E) | Untreated | P10 (A) vs. P14 (C) | P14 (B) vs. P14 (C) |
| A-wave | 250 ± 21 | 38 ± 6 | 203 ± 17 | 158 ± 16 | 0 ± 0 | 0 ± 0 | 0 ± 0 | <0.001 | <0.001 |
| B-wave | 590 ± 61 | 249 ± 35 | 470 ± 50 | 390 ± 44 | 75 ± 9 | 16 ± 3 | 0 ± 0 | <0.001 | <0.001 |
The AAV8 (Y733F) vector was used to treat rd11 mice at P10 (Group A), P14 (Group B, C), P18 (Group D) or P22 (Group E). Groups A, C, D, and E were with normal light exposure, but group B with limited light exposure.
Data presented as mean ± standard deviation. n = 8 mice for each group examined. P values calculated using a multiple comparison procedure (LSD test).