Table 5. Effect of 5-ASA on association with tissue cytokines and serum fatty acids.
| No 5-ASA use (n = 9) | Current 5-ASA use (n = 49) | |||
|---|---|---|---|---|
| r | P | r | P | |
| %SFA | ||||
| Eotaxin-1 | 1.00 | <0.001 | 0.45 | 0.002 |
| G-CSF | 0.63 | 0.060 | 0.38 | 0.008 |
| IL-6 | 0.95 | <0.001 | 0.30 | 0.047 |
| TNF-α | 0.89 | 0.007 | 0.31 | 0.034 |
| IL-8 | 0.88 | 0.004 | 0.30 | 0.036 |
| IL-17 | 0.83 | 0.005 | 0.30 | 0.042 |
| %PUFA | ||||
| Eotaxin-1 | −0.93 | 0.003 | −0.38 | 0.010 |
| G-CSF | −0.75 | 0.020 | −0.37 | 0.009 |
| IL-8 | −0.81 | 0.015 | −0.34 | 0.018 |
| %EPA | ||||
| G-CSF | −0.48 | 0.188 | −0.34 | 0.019 |
| IL-6 | −0.81 | 0.015 | −0.24 | 0.107 |
| TNF-α | −0.86 | 0.014 | −0.35 | 0.016 |
| %DPA | ||||
| Eotaxin-1 | −0.67 | 0.102 | −0.30 | 0.045 |
Serum fatty acid and tissue cytokine associations identified as significant (Fig 3) were reanalyzed by use of 5-ASA in UC subjects only. Spearman correlation coefficient (r) and the associated P value are shown.