Fig 3. Number of affected and unaffected individuals with high polygenic lipid scores or carriers of high-impact Mendelian variants.
The black shading presents the number of (a) affected, and (b) unaffected individuals with high polygenic lipid scores (LDL-C, TG, or both polygenic scores over the 90th percentile in the population) or carriers of a high-impact Mendelian variant (APOE ɛ2ɛ2, n = 2; or homozygosity for APOA5 rs3135506). The families are sorted by the number of affected individuals with high polygenic lipid scores or a high-impact Mendelian variant in (a). The grey shading presents the number of other (a) affected, and (b) unaffected individuals in the family.