Table 1. Clinical and metabolic characteristics of genotyped individuals.
| FCH affected | FCH unaffected | ||||
|---|---|---|---|---|---|
| Characteristic | n | Mean ± SD | n | Mean ± SD | p-value |
| n (male/female) | 234 (108/126) | 481 (243/238) | 0.27 | ||
| Smoking, n (%) | 75 (32) | 122 (25) | 0.50 | ||
| Age (year) | 233 | 42.7±14.2 | 477 | 40.6±14.8 | 0.08 |
| BMI (kg/m2) | 232 | 27.6±4.7 | 464 | 25.5±4.7 | 2.21x10-6 |
| Waist circumference (cm) | 190 | 93±14 | 370 | 86±14 | 3.80x10-7 |
| Total cholesterol (mmol/l) | 211 | 6.64±1.36 | 403 | 5.18±0.92 | 1.97x10-53 |
| LDL-C (mmol/l) | 211 | 4.29±1.23 | 403 | 3.30±0.89 | 6.64x10-29 |
| Triglyceride (mmol/l) | 211 | 2.51±1.85 | 403 | 1.13±0.48 | 3.77x10-45 |
| HDL-C (mmol/l) | 208 | 1.23±0.40 | 395 | 1.40±0.41 | 1.23x10-6 |
| Apolipoprotein B (mg/dl) | 192 | 126±32 | 378 | 87±22 | 5.74x10-65 |
| Non-HDL-C | 208 | 5.41±1.39 | 395 | 3.78±0.95 | 1.99x10-62 |
P-values were calculated using Wald test by a linear mixed model correcting for sample relatedness. FCH, familial combined hyperlipidemia.