Table 1. Clinical Characteristics at Presentation, First and Second Recurrences.

M = male; sAFP = serum AFP; cAFP = CSF AFP; VP = ventriculoperitoneal; carbo = carboplatin; ifos = ifosfamide; VP-16 = etoposide; chemo = chemotherapy; WVI = whole ventricular irradiation; CR = complete response; RT = radiation therapy; ETV = endoscopic third ventriculostomy; PR = partial response; GemPOx = gemcitabine, paclitaxel, oxaliplatin; ASCR = autologous hematopoietic stem cell rescue; CSI = craniospinal irradiation; RT = radiotherapy

Case	Age / Sex	Histology	Extent of Disease	Tumor Markers	Surgery	Chemo	Chemo Response	Progression	Treatment & Response	Second Recurrence
1	16M	-	Pineal	sAFP 49.3 ng/mL, cAFP 33.9 ng/mL	Tumor bleed and VP shunt	Carbo/VP-16, Ifos/VP-16	CR post-6th cycle	1 month post-chemo, sAFP 8.9 ng/mL	WVI 36 Gy, plus boost to 54 Gy, CR	3 months post-RT, cAFP 11.4 ng/mL
2	17M	Yolk sac 80% and germinoma 20%	Pineal	sAFP 755 ng/mL, cAFP 350 ng/mL	ETV and biopsy	Carbo/VP-16, Ifos/VP-16	PR post-6th cycle	2 months post-chemo, sAFP 17.8 ng/mL	GemPOx with ASCR, PR, sAFP 5.2 ng/mL, then CSI 36 Gy, plus boost to 54 Gy, CR	29 months post-RT, sAFP 6120 ng/mL, and cAFP 3000 ng/mL