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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Mar 24;36(6):1197–1208. doi: 10.1161/ATVBAHA.116.307421

Figure 7.

Figure 7

Model showing potential mechanism by which an LPA/PKD-1-HDAC7-FoxO1 signaling axis regulates EC CD36 transcription and angiogenesis. LPA signaling in MVEC is mediated by G-protein coupled LPA receptors 1 and 3 at the EC membrane (M) which activate protein kinase PKD-1, leading to PKD-1 and HDAC7 translocation into the nucleus (N) where they interact with the transcription factor FoxO1 and the co-repressor NCoR1. This results in CD36 transcriptional repression and reprogramming EC to express ephrinB2 which promotes angiogenesis, arteriogenic differentiation and microvascular remodeling.