Table 1.
Body weight (BW), total serum cholesterol (TC) and triglyceride (TG) levels in male Ldlr−/− mice reconstituted with WT, Jnk1−/−, Jnk2−/−, Jnk1+/−/Jnk2−/− and Jnk1−/−/Jnk2+/− hematopoietic cells on chow and high-fat diets
| Chow diet | High-fat diet | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Type of bone marrow reconstituted | BW (g) | TC (mg/dl) | TG (mg/dl) | BW (g) | TC (mg/dl) | TG (mg/dl) |
| A. | ||||||
| WT (n=14) | 29.3±0.6 | 242±11 | 125±4 | 32.3±0.7 | 1063±49 | 453±40 |
| Jnk1−/− (n=11) | 27.8±0.5 | 245±16 | 137±5 | 29.8±0.9 | 1030±74 | 472±79 |
| Jnk2−/− (n=13) | 28.0±0.8 | 213±13 | 135±6 | 29.9±0.4 | 1073±84 | 465±59 |
| p = | 0.21 | 0.20 | 0.15 | 0.75 | 0.44 | 0.90 |
|
| ||||||
| B. | ||||||
| WT (n=10) | 28.0±0.7 | 208±4 | 116±6 | 30.8±1.2 | 974±98 | 322±21 |
| Jnk1−/− (n=10) | 26.9±0.6 | 216±8 | 121±5 | 30.3±2.2 | 982±62 | 362±39 |
| Jnk1+/−/2−/−(n=13) | 27.3±0.9 | 218±9 | 118±3 | 29.7±1.1 | 955±52 | 334±13 |
| Jnk1−/−/2+/−(n=12) | 27.2±0.8 | 213±5 | 121±5 | 29.3±0.7 | 966±48 | 345±24 |
| p = | 0.66 | 0.75 | 0.12 | 0.33 | 0.99 | 0.72 |
Values are in mg/dl (Mean ± SEM). The number of recipient mice in each group is indicated by n. The differences are not statistically significant between the groups by One Way ANOVA.