Table 2.

Differentially expressed proteins among MHO and MAO African‐American women determined by label‐free serum proteomics

Accession #	Protein name	Gene symbol	Log effect size (log2FC)	P MHO unadjusted	P MHO BH	Average PC in MHO	Average PC in MAO
8 under‐expressed proteins in MHO compared with MAO
P69905	Hemoglobin subunit alpha	HBA1	−1.17	3.1 × 10−21	6.00 × 10−18	8.5	27.5
P00739	Haptoglobin‐related protein	HPR	−0.78	7.6 × 10−19	1.2 × 10−15	19.2	42.1
P68871	Hemoglobin subunit beta	HBB	−0.80	4.6 × 10−15	4.5 × 10−12	13.8	30.8
P00751	Complement factor B	CFB	−0.21	1.4 × 10−10	1.1 × 10−07	172.7	212.6
Q14624	Inter‐alpha‐trypsin inhibitor heavy chain H4	ITIH4	−0.16	3.0 × 10−09	1.70 × 10−06	242	285.1
P02741	C‐reactive protein	CRP	−2.13	4.00 × 10−07	2.0 × 10−04	1.2	10.1
P27169	Serum paraoxonase1	PON1	−1.16	1.5 × 10−06	7.0 × 10−04	2.44	7.8
P0C0L4	Complement C4‐A	C4A	−0.081	2.8 × 10−06	1.0 × 10−03	638.4	692.5
12 over‐expressed proteins in MHO compared with MAO
P04114	Apolipoprotein B‐100	APOB	0.28	1.9 × 10−44	1.5 × 10−40	563.1	423.7
P02765	Alpha‐2‐HS‐glycoprotein	AHSG	0.75	7.7 × 10−33	3.00 × 10−29	79.1	37.4
P01008	Antithrombin‐III	SERPINC1	0.41	3.50 × 10−26	9.2 × 10−23	163.8	108.2
P06727	Apolipoprotein A‐IV	APOA4	0.40	8.5 × 10−18	1.10 × 10−14	113.8	76.1
P05155	Plasma protease C1 inhibitor	SERPING1	0.71	4.6 × 10−15	4.5 × 10−12	37	18.2
P02753	Retinol‐binding protein 4	RBP4	0.46	8.1 × 10−11	7.1 × 10−08	51.5	32.5
P19823	Inter‐alpha‐trypsin inhibitor heavy chain H2	ITIH2	0.19	2.3 × 10−10	1.6 × 10−07	249.5	206.6
P06396	Gelsolin	GSN	0.25	3.4 × 10−10	2.25 × 10−07	135.1	104.3
P04196	Histidine‐rich glycoprotein	HRG	0.30	8.9 × 10−10	5.3 × 10−07	99.4	73.8
P19827	Inter‐alpha‐trypsin inhibitor heavy chain H1	ITIH1	0.15	7.5 × 10−07	0.0004	228.9	196.6
P02774	Vitamin D‐binding protein	GC	0.17	1.7 × 10−06	0.0007	165.8	139.3
P10643	Complement component C7	C7	0.36	1.8 × 10−05	0.007	34.9	24.4

Cutoff P‐value < 0.05.