Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Drug Discov Today. 2015 Nov 26;21(6):989–996. doi: 10.1016/j.drudis.2015.11.008

Figure 2.

Figure 2

Peptide 2 (pep2) inhibits B cell lymphoma 2 (Bcl-2) BH4–IP3R interaction and IP3R-induced Ca2+ elevation to induce apoptosis. (a) The sequences of pep1, pep2 and ctrlpep are shown. (b) pep2 reverses Bcl-2 inhibition of anti-CD3-induced Ca2+ elevation in Bcl-2(+) WEHI7.2 cells. (c) pep2 enhances anti-CD3-induced apoptosis in Bcl-2(+) WEHI7.2 cells. (d) BH4 domain is required for Bcl-2–IP3R interaction. Reproduced, with permission, from [32,37].