Table 1.
Feature | SIR-Spheres® | TheraSphere® |
Isotope | 90Y | 90Y |
Half life (h) | 64.2 | 64.2 |
Material | Resin | Glass |
Diameter (μm) | 20-60 | 20-30 |
Activity per particle (Bq) | 50 | 2500 |
Spheres per 3 GBq | 40-80 × 106 | 1.2 × 106 |
Specific Gravity (g/mL) | 1.6 | 3.2 |
Embolic effect | Mild | Negligible |
Contrast injection | During infusion | No |
FDA approved indication | CRC liver metastases with intrahepatic floxuridine | HCC |
FDA: Food and Drug Administration; CRC: Colorectal cancer; HCC: Hepatocellular carcinoma.