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. 2016 Mar 23;291(22):11491–11503. doi: 10.1074/jbc.M115.702092

FIGURE 7.

FIGURE 7.

Emodin inhibits LPS/IFNγ- and IL4-induced histone modifications in macrophages. Macrophages were stimulated with LPS (100 ng/ml) and IFNγ (20 ng/ml) or IL4 (10 ng/ml) with or without emodin (50 μm) for 24 h. A, global histone modification levels were detected using Western blotting. The experiment was performed in triplicate. Con, control; Em, emodin. B and C, ChIP-PCR was used to detect gene-specific changes in histone modifications. Results are shown as the mean ± S.E. (n = 3). *, p ≤ 0.05; **, p ≤ 0.01.

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