Figure 2.

Schematic of the key metabolic pathways in cardiac myocytes. Fatty acid and glucose metabolism are key metabolic pathways within cardiac myocytes that are responsible for generating large amounts of ATP. Perhexiline and nitrite are therapeutic agents that have the ability to modulate and enhance cardiac metabolism. Acetyl CoA, acetyl coenzyme A; ADP, adenosine diphosphate; ATP, adenosine triphosphate; CPT, carnitine palmitoyltransferase; ETC, electron transport chain; FADH₂, flavin adenine dinucleotide; NADH, nicotine adenine dinucleotide; P_i, inorganic phosphate; TCA, tricarboxylic acid.