Table 2. The effects of CA on the characteristics and biochemical parameters of STZ-treated rats (n = 8).
Groups | Body weights (g) | Kidney weight (g) | Kidney index (×10−3) | Albuminuria (μg/day) | BUN (mmol/L) | Serum creatinine (μmol/L) |
---|---|---|---|---|---|---|
Control | 486.16 ± 17.43# | 3.37 ± 0.11# | 6.95 ± 0.16# | 14.27 ± 0.87# | 5.40 ± 0.51# | 28.57 ± 1.85# |
Model | 353.60 ± 10.77* | 3.77 ± 0.19* | 10.66 ± 0.35* | 94.78 ± 4.52* | 12.17 ± 1.35* | 45.41 ± 3.50* |
Model + CA (5 mg/kg) | 387.37 ± 12.91*,# | 3.68 ± 0.16 | 9.55 ± 0.47*,# | 85.98 ± 4.58* | 11.50 ± 0.71* | 41.10 ± 2.47* |
Model + CA (10 mg/kg) | 425.20 ± 18.25*,# | 3.46 ± 0.17 | 8.18 ± 0.21*,# | 82.00 ± 4.13*,# | 11.16 ± 1.11* | 38.29 ± 2.20* |
Model + CA (20 mg/kg) | 446.55 ± 15.98# | 3.40 ± 0.17 | 7.65 ± 0.45# | 72.14 ± 5.21*,# | 9.14 ± 0.64*,# | 32.68 ± 3.69# |
Model + Enalapril (10 mg/kg) | 388.97 ± 17.18*,# | 3.60 ± 0.21 | 9.25 ± 0.33*,# | 78.79 ± 3.23*,# | 11.00 ± 0.82* | 38.64 ± 2.60* |
CA (10 mg/kg) | 480.82 ± 24.19# | 3.31 ± 0.17# | 6.87 ± 0.11# | 15.05 ± 1.59*,# | 5.52 ± 0.77# | 28.98 ± 1.87# |
*P < 0.05 vs. control; #P < 0.05 vs. model.